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Posts Tagged ‘screening’

It’s good news to those who prefer to study MBBS abroad. Yes, previously, there was a need of eligibility certificate provided by the MCI (Medical Council of India) which was mandatory to be submitted during admissions. But now, the eligibility certificate is not mandatory! However, they have to fill the eligibility criteria as per the […]

PMDC Exam 2013 Step 1 Anatomy: Give an Account on development of Right Atrium? [5] Give an Account on Great Sephanous Vein? [5] Describe the anatomy of Inguinal Canal, and also describe its Applied Anatomy? [5] Describe the Lymphatic drainage of Breast? [5] Physiology: Define Cardiac Output? How do you Measure it? [5] Write the […]

Blood pressure is typically recorded as two numbers, written as a ratio like this: Read as “117 over 76 millimeters of mercury” Systolic The top number, which is also the higher of the two numbers, measures the pressure in the arteries when the heart beats (when the heart muscle contracts). Diastolic The bottom number, which […]

4. Catabolism of sugars other than glucose 4.3 Lactose and galactose The Leloir pathway for galactose utilization Mechanism of UDP-galactose epimerase Lactose intolerance Galactosemia Lactose, a disaccharide of glucose and galactose, is the major carbohydrate contained in milk. Like maltose and sucrose, it is cleaved at the brush border of the small intestine, and the […]

1. Introduction 1.2 Significance of metabolism in medicine Hereditary enzyme defects Diabetes, atherosclerosis, gout Antimetabolites in the chemotherapy of cancers and infections Inactivation and elimination of xenobiotics and drugs Metabolism is a central theme in biochemistry; it keeps cells and organisms alive, by giving them the energy they need to carry on and the building […]

15. Drug discovery 15.3 Compound screening Peptide deformylase and Met aminopeptidase In vitro screening of Met aminopeptidase inhibitors A non-covalent yet irreversible enzyme inhibitor A generic assay for GPCR activation A cell-based fluorescence assay of membrane depolarization A fluorescence assay of Ca++ influx An in silico docking experiment Electrostatic potential mapped onto the electronic density for acetaminophen Hypothetical pharmacophore for […]

15. Drug discovery 15.1 Stages of drug discovery Chemical structures of subtype-selective glutamate receptor ligands Target molecule selection validation Candidate compounds acquisition screening Biochemical and physiological discoveries suggest macromolecules that might make worthwhile targets for treating diseases. This is an important step toward new drugs, but only the first one. The subsequent steps that must […]

1. Introduction 1.3 Drug discovery and development Arsphenamine, the first modern antibacterial drug Paul Ehrlich, the discoverer of both arsphenamine and the receptor concept Drug discovery by brute force: Sulfamidochrysoidine Natural compounds and semisynthetic derivatives Protein structure-based drug discovery: HIV protease bound to its inhibitor saquinavir Structure of saquinavir, and its conformation in the active […]

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