autonomic

Overview of glucose metabolism

Published: 16 May 2014
Categories: Metabolism

3. Glycolysis 3.1 Overview of glucose metabolism The place of glycolysis in glucose degradation Alternative structures of d-glucose Pathway Function glycolysis, citric acid cycle, respiratory chain complete degradation of glucose for ATP production hexose monophosphate shunt degradation of glucose for regeneration of NADPH glycogen synthesis…

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NO-releasing drugs

Published: 15 May 2014
Categories: Pharmacology

8. Pharmacology of nitric oxide 8.7 NO-releasing drugs Release of NO from nitroglycerin and ISDN by human cytochrome P450 isoforms NO release by molsidomine The drugs shown in this slide are used in the treatment of hypertension and of stenoticcoronary artery disease. The first drug to be so employed…

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Identification of “endothelium-derived relaxing factor” as nitric oxide

Published: 15 May 2014
Categories: Pharmacology

8. Pharmacology of nitric oxide 8.2 Identification of “endothelium-derived relaxing factor” as nitric oxide Cholinergic and adrenergic nerve endings in a blood vessel wall The endothelium is required for vascular relaxation in response to acetylcholine Vasorelaxation mediated by nitric oxide is controlled by the autonomic nervous system. The…

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Physiological significance of nitric oxide (NO)

Published: 15 May 2014
Categories: Pharmacology

8. Pharmacology of nitric oxide 8.1 Physiological significance of nitric oxide (NO) Powerful vasodilator—NO-releasing drugs are used in the treatment of cardiovascular disease Inflammatory mediator—inhibition of NO synthesis is of interest as a therapeutic strategy in infection and chronic inflammation Neurotransmitter—signaling in the CNS and the autonomic nervous system…

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Pharmacology of cholinergic synapses

Published: 15 May 2014
Categories: Pharmacology

6. Pharmacology of cell excitation 6.15 Pharmacology of cholinergic synapses Structures of cholinergic receptor agonists Structures of cholinergic receptor antagonists The catalytic mechanism of cholinesterase Covalent inactivation of cholinesterase by DFP, and reactivation by oximes Structures of cholinesterase inhibitors and of a reactivator As discussed above, acetylcholine has…

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The autonomic nervous system

Published: 15 May 2014
Categories: Pharmacology

6. Pharmacology of cell excitation 6.13 The autonomic nervous system Organization of the autonomic nervous system Transmitter receptors in the peripheral autonomic nervous system The autonomic nervous system is the part of our nervous system that is not under conscious control. It controls many physiological functions, and therefore…

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Structure, function and pharmacology of the cys-loop receptor family

Published: 15 May 2014
Categories: Pharmacology

6. Pharmacology of cell excitation 6.10 Structure, function and pharmacology of the cys-loop receptor family Structure of the nicotinic acetylcholine receptor Trapping the nicotinic acetylcholine receptor in the open state Photoaffinity labeling of the acetylcholine binding site Isolation of affinity-labeled polypeptide chains and fragments Identification of affinity-labeled amino acid residues…

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Pharmacology of calcium channels

Published: 15 May 2014
Categories: Pharmacology

6. Pharmacology of cell excitation 6.7 Pharmacology of calcium channels Two calcium channels control the contraction of striated muscle cells Entry of Ca++ through the DHPR is necessary in the heart, but not in skeletal muscle cells Inhibitors of voltage-gated calcium channels Structure of ?-conotoxin, an inhibitor of N-type CaV channels Agonists…

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